Bioactive Small Molecules
Cayman Chemical Glucagon (hydrochloride), Purity: ≥95%, CAS: 19179-82-9, 5 mg
A peptide hormone; produced from proglucagon in pancreatic α cells; stimulates glucose production ex vivo in isolated rat hepatocytes; stimulates glucose output from perfused rat livers via increases in gluconeogenesis and glycogenolysis and decreases in glycolysis; increases plasma glucose levels in rats; secretion is suppressed in response to food intake in normal rats and humans but is maintained or elevated in humans with type 2 diabetes
Medchemexpress LLC 8-Bromoadenosine | 2946-39-6 | 99.73% | 346.14 | 5 G
8-Bromoadenosine is an adenosine analog. Adenosine analogs primarily function as smooth muscle vasodilators and have been shown to hinder cancer progression. It can quench the intrinsic fluorescence of human serum albumin (HSA) through a static quenching procedure. It can be utilized to synthesize adenosine phosphates, such as Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine.
- Reduces the fluorescence emission intensity of HSA.
- Binds to HSA with reduced stability as temperature increases, though the temperature effect is minimal.
- Exhibits decreased binding constants with HSA in the presence of other ions.
Medchemexpress LLC Sodium phosphate dib 50g
Sodium phosphate dibasic dihydrate for molecular biology is an inorganic salt compound Sodium phosphate dibasic dihydrate for molecular biology is commonly used in molecular biology experiments and can be used as a buffer nutritional supplement and detergent
AdipoGen Combretastatin A4 (50 mg)
Chemical. CAS: 117048-59-6. Formula: C18H20O5. MW: 316.35. Combretastatin A4 is a natural stilbenoid phenol originally isolated from an African shrub, Combretum caffrum. It is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma) and MCF-7 (breast cancer). It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.
Medchemexpress LLC Pironetin 5mg | 151519-02-7 | 5 MG
Pironetin is a research reagent that binds α-tubulin and inhibits microtubule polymerization, producing cell-cycle arrest and cytotoxic effects in various cell lines. It is supplied in small, measured milligram quantities for in vitro laboratory use.
- Microtubule/tubulin inhibitor that binds α-tubulin.
- Suitable for in vitro cell-cycle and cytotoxicity studies.
- Available in small milligram pack sizes for assay development.
- Chemical formula C19H32O4; molecular weight 324.45 g/mol.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC SX-682 | 1648843-04-2 | 99.7% | 467.20 | 100 MG
SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. It can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.
- Orally bioavailable
- Potent allosteric inhibitor of CXCR1 and CXCR2
- Blocks tumor myeloid-derived suppressor cells (MDSCs) recruitment
- Enhances T cell activation and antitumor immunity
Medchemexpress LLC I-BET151 | 1300031-49-5 | 99.47% | 415.44 | 100 MG
I-BET151 (GSK1210151A) is a BET bromodomain inhibitor that inhibits BRD4, BRD2, and BRD3. It is intended for research use only and has shown antiproliferative activity in various cell lines, as well as reduced tumor size in in vivo models.
- Inhibits BRD4, BRD2, and BRD3
- Shows antiproliferative activity in various cell lines
- Significantly decreases cell proliferation and tumor size in in vivo models
- Exhibits low blood clearance in rats and good oral systemic exposure
![Cayman Chemical [Nle4,D-Phe7]-α-MSH (acetate), Purity: ≥98%, CAS: 1566590-77-9, 5 mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Cayman Chemical [Nle4,D-Phe7]-α-MSH (acetate), Purity: ≥98%, CAS: 1566590-77-9, 5 mg
A peptide agonist of MC1R; induces cAMP accumulation in mouse L-cells expressing human MC1R (EC50 = 0.5 nM); induces tyrosinase activity in mouse melanoma cells; induces long-term skin darkening in frogs at 1.8 mg/kg
Cayman Chemical LY2608204, Purity: ≥98%, CAS: 1234703-40-2, 1 mg
An activator of glucokinase (EC50 = 42 nM); stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM); decreases plasma glucose levels in a dose-dependent manner in fasted rats (30 mg/kg)
Medchemexpress LLC P Glycoprotein Antibody (YA255) | 100 UL
P Glycoprotein Antibody (YA255) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting P Glycoprotein, a member of the ATP-binding cassette (ABC) transporter superfamily. P Glycoprotein acts as an ATP-dependent drug efflux pump, contributing to multidrug resistance in cells and functioning as a transporter in the blood-brain barrier. It is associated with colchicine resistance and Inflammatory bowel disease 13.
- Host: Rabbit
- Reactivity: Human
- Conjugation: Non-conjugated
- SwissProt ID: P08183
- Research field: Signal transduction
- Predicted molecular weight: 141 kDa
- Observed molecular weight: 130-180 kDa
- Formulation: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.05% BSA, 0.01% Sodium azide
- Appearance: Liquid
- Applications: WB, IHC-P
- Storage: Stored at -20°C for 1 year; avoid repeated freeze/thaw cycles
Cayman Chemical SHA-68, Purity: ≥95%, CAS: 847553-89-3, 25 mg
An NPSR antagonist (IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively); selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM; reduces NPS-induced horizontal activity and vertical rearing and climbing in mice when administered at a dose of 50 mg/kg; reduces conditioned reinstatement of cocaine seeking in rats
Cayman Chemical U-48520, Purity: ≥98%, CAS: 67579-11-7, 1 mg
An analytical reference standard categorized as a utopioid; intended for research and forensic applications
Cayman Chemical ANTIBODY BPIPP 1mg
A non-competitive inhibitor of guanylyl and adenylyl cyclases; suppresses STa-, guanylin-, atrial natriuretic peptide-, and C-type natriuretic peptide-induced cGMP accumulation in cells (IC50s = 3.4-11.2 μM); inhibits STa-, forskolin-, cholera toxin-, and isoproterenol-induced chloride efflux in T84 cells; suppresses STa-induced liquid secretion in a rabbit intestinal loop model of toxin-induced secretory diarrhea (10 or 50 μM)
Medchemexpress LLC Ido1/tdo-in-4 | 461424-21-5 | C14H10N4 | 5 MG
IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). It forms a hydrogen bond with IDO1 and π-π stacking interaction with TDO. This product can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders.
- Potent IDO1/TDO dual inhibitor.
- IC50 values: 3.53 μM (IDO1) and 1.15 μM (TDO).
- Forms hydrogen bond with IDO1 and π-π stacking interaction with TDO.
- Can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders.
Medchemexpress LLC Z-Glu-OBzl | 3705-42-8 | MFCD00077013 | 371.38 | 100 G
Z-Glu-OBzl is a glutamic acid derivative. Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks, and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
- Influences the secretion of anabolic hormones.
- Supplies fuel during exercise.
- Improves mental performance during stress-related tasks.
- Prevents exercise-induced muscle damage.
- Recognized as an ergogenic dietary substance.